Analytical Data
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基因名
SREBF2
- Application
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别名
SREBF2; BHLHD2; SREBP2; Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12772
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表达区间
801-900 aa
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氨基酸序列
QAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT
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分子量
36.63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SREBF2, or Sterol Regulatory Element-Binding Protein 2, is a key transcription factor that plays a crucial role in lipid metabolism and homeostasis. It primarily regulates the expression of cholesterol and fatty acid synthesis genes, making it vital for cellular and organismal health. Research into SREBF2 has gained momentum due to its implications in various metabolic disorders, including dyslipidemia, obesity, and cardiovascular diseases. Dysregulation of SREBF2 activity can lead to altered lipid profiles and contribute to the pathogenesis of these conditions. Consequently, scientists have focused on understanding the molecular mechanisms governing SREBF2 expression and function, with the aim of identifying potential therapeutic targets for metabolic diseases. The study of recombinant SREBF2 protein has provided valuable insights into its structural and functional properties, enabling more defined investigations into its role in lipid regulation. By producing and analyzing SREBF2 in a controlled environment, researchers can explore its interactions with other biomolecules, as well as the downstream signaling pathways it influences. This research not only enhances our understanding of lipid metabolism but also contributes to the development of strategies for combating metabolic diseases linked to SREBF2 dysregulation. Overall, the ongoing studies on recombinant SREBF2 protein are pivotal in elucidating its role in metabolism and its potential as a therapeutic target in metabolic-related diseases.












