Analytical Data
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Gene name
NRARP
- Application
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Alternative Names
NRARP；Notch-regulated ankyrin repeat-containing Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z6K4
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Expression Region
1-114aa
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AA Sequence
MSQAELSTCS APQTQRIFQE AVRKGNTQEL QSLLQNMTNC EFNVNSFGPE GQTALHQSVI DGNLELVKLL VKFGADIRLA NRDGWSALHI AAFGGHQDIV LYLITKAKYA ASGR
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NRARP (Notch-regulated ankyrin repeat protein) is an important player in the Notch signaling pathway, which is crucial for various developmental processes and cell fate determination. Impairments in the Notch pathway have been linked to several diseases, including cancer, making NRARP a significant target for research. Previous studies have demonstrated that NRARP acts as a transcriptional co-regulator, influencing the expression of genes that govern cell differentiation and proliferation. Additionally, NRARP is implicated in the regulation of hair cell development in the inner ear, contributing to the understanding of hearing loss mechanisms. The study of NRARP recombinant proteins has gained attention as researchers aim to elucidate its molecular functions and interactions within the Notch signaling cascade. By producing NRARP in a recombinant form, scientists can investigate its structural properties, binding affinities, and functional roles in various biological contexts. This research not only enhances our understanding of the fundamental biological processes regulated by NRARP but also paves the way for potential therapeutic targets for diseases associated with dysregulated Notch signaling. Overall, the investigation of NRARP recombinant proteins serves as a vital step toward unraveling the complexity of cell signaling pathways and their implications in health and disease.
