Analytical Data
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Gene name
DHRS12
- Application
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Alternative Names
DHRS12; SDR40C1Dehydrogenase/reductase SDR family member 12; EC 1.1.-.-; Short-chain dehydrogenase/reductase family 40C member 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0PJE2
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Expression Region
1-317aa
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AA Sequence
MSLYRSVVWF AKGLREYTKS GYESACKDFV PHDLEVQIPG RVFLVTGGNS GIGKATALEI AKRGGTVHLV CRDQAPAEDA RGEIIRESGN QNIFLHIVDL SDPKQIWKFV ENFKQEHKLH VLINNAGCMV NKRELTEDGL EKNFAANTLG VYILTTGLIP VLEKEHDPRV ITVSSGGMLV QKLNTNDLQS ERTPFDGTMV YAQNKRQQVV LTERWAQGHP AIHFSSMHPG WADTPGVRQA MPGFHARFGD RLRSEAQGAD TMLWLALSSA AAAQPSGRFF QDRKPVSTHL PLATASSSPA EEEKLIEILE QLAQTFK
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Molecular Weight
35.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The DHRS12 gene, belonging to the short-chain dehydrogenase/reductase (SDR) family, encodes an enzyme that plays a crucial role in various metabolic processes, particularly in the reduction of ketones and aldehydes. Research into DHRS12 has gained traction due to its potential implications in health and disease, including metabolic disorders and certain forms of cancer. The enzyme's ability to convert steroid hormones and intermediates in lipid metabolism suggests its importance in maintaining endocrine homeostasis. Furthermore, emerging studies have indicated that DHRS12 might be involved in mechanisms of oxidative stress, which are linked to various pathologies including neurodegenerative diseases. Understanding the structural and functional characteristics of the DHRS12 protein can provide insights into its specific biological roles and regulatory mechanisms. Recent advances in recombinant protein technology have facilitated the production of DHRS12 for in vitro studies, enabling researchers to elucidate its enzymatic activity, substrate specificity, and interaction with other biomolecules. The study of DHRS12 thus holds promise not only for elucidating metabolic pathways but also for developing therapeutic strategies for related diseases.
