Analytical Data
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基因名
SPATA5
- Application
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别名
SPATA5; AFG2; SPAF; ATPase family protein 2 homolog; EC 3.6.4.10; Spermatogenesis-associated factor protein; Spermatogenesis-associated protein 5
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NB90
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表达区间
1-695 aa
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氨基酸序列
MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKDDKIPKTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKNVGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDLEDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGNEQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKVGC
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分子量
102 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPATA5, or Spermatogenesis Associated 5, is a protein that has garnered interest due to its potential roles in male fertility and spermatogenesis. The gene encoding SPATA5 is primarily expressed in the testis, suggesting its critical function in male reproductive biology. Recent studies have highlighted SPATA5’s involvement in various cellular processes, including mitochondrial function and protein synthesis, which are essential for the proper development and maintenance of sperm cells. Given the increasing incidence of male infertility globally, understanding the molecular mechanisms involving SPATA5 could provide insights into potential therapeutic targets for reproductive disorders. Furthermore, the investigation of SPATA5 recombinant proteins has become pivotal in elucidating its structure-function relationship, facilitating studies on protein interactions and cellular pathways it may influence. Through advanced techniques such as CRISPR gene editing and protein engineering, researchers aim to clarify SPATA5's specific roles in spermatogenic processes and its implications in male infertility. As research progresses, the characterization of SPATA5 and its recombinant forms is expected to contribute significantly to reproductive biology and potentially lead to innovative strategies for addressing infertility issues.
