Analytical Data
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Gene name
RAD54L2
- Application
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Alternative Names
RAD54L2；ARIP4；KIAA0809；Helicase ARIP4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y4B4
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAD54L2, a member of the RAD54 protein family, plays a crucial role in the DNA damage repair process, particularly in homologous recombination, which is vital for maintaining genomic stability. This ATP-dependent DNA motor protein facilitates the remodeling of chromatin to enhance the accessibility of DNA substrates for repair proteins. Recent studies have highlighted RAD54L2's importance in the cellular response to DNA double-strand breaks and its potential involvement in various malignancies due to its role in genomic integrity. The research on RAD54L2 has been driven by the need to understand its specific functions, mechanisms of action, and the pathways in which it participates. Investigating RAD54L2's interactions with other repair proteins and its regulation in cell cycle checkpoints is essential for unraveling its contribution to both normal cellular functions and tumorigenesis. Additionally, exploring RAD54L2’s variation among different populations may offer insights into individual susceptibility to cancer and responses to DNA-damaging therapies. Overall, RAD54L2 is emerging as a significant protein in the field of molecular biology and cancer research, providing a potential target for therapeutic interventions aimed at improving DNA repair efficiency in cancer cells.
