Analytical Data
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Gene name
DGCR14
- Application
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Alternative Names
DGC14_HUMAN; DGCR13; DGCR14; DGS H; DGS I; DGS-H; DGSH; DGSI; DiGeorge syndrome critical region 13; DiGeorge syndrome critical region 14; DiGeorge syndrome critical region gene 14; DiGeorge syndrome critical region gene DGSI
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96DF8
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Expression Region
1-395aa
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AA Sequence
MLGACFPNLSSGDVMVFGPGGLGQPVLHPVLVLGHHQQPVLGFGSKLVVGPVVGPQACLGVQFALSAVLALPLPLEGGRRRGFGLGGLQPRVAEDLIDVEPLADVGLQHAVDEVLALAGQVLGAREVHTVLLLDTQHLPDVGVVIGHGAADHDVQDHAQAPDVIHLGLVGDALQHLGGCICCRPAEGLAEDDAPIAVPQAALGEAKVRQLDVEVLVEEKVLALEVPVDDVQVVAVLDGGGELSEHLACHVLMQGSLALDELEKRLAPLPSTSPRHVGQQALSSFTLPEASGWAALGWASTQGWDTQHCLRVTSANELIKPRSGGGDWAEGEQGLWNRGSQAGLAGAPTPRPLEGSLSPGQDSGGPAAAALVSLSQVKLEGRRPTSSLFASPGCGD
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DGCR14, a member of the DiGeorge syndrome critical region gene 14 family, has garnered attention due to its role in cellular processes and its potential implications in various diseases. Initially identified in the context of DiGeorge syndrome, a genetic disorder characterized by thymic, parathyroid, and cardiac anomalies, DGCR14 is located within a chromosomal region frequently deleted in this syndrome. Recent studies have revealed that DGCR14 is involved in critical biological functions, including immune system modulation and cellular signaling pathways, particularly those related to development and differentiation. The protein has been shown to interact with numerous cellular partners, suggesting its importance in complex molecular networks. Furthermore, aberrations in DGCR14 expression or function have been linked to disorders such as cancer and other developmental anomalies, highlighting the need for a comprehensive understanding of its biological roles. As a result, research has increasingly focused on the recombinant production of DGCR14 to study its structure and function in detail. This recombinant protein serves as a valuable tool for exploring its interactions and mechanisms, potentially paving the way for therapeutic strategies targeting diseases associated with DGCR14 dysregulation. Understanding the specifics of DGCR14’s role in health and disease could significantly advance our knowledge of genetic disorders and contribute to the development of novel interventions.
