Analytical Data
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基因名
DGCR14
- Application
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别名
DGC14_HUMAN; DGCR13; DGCR14; DGS H; DGS I; DGS-H; DGSH; DGSI; DiGeorge syndrome critical region 13; DiGeorge syndrome critical region 14; DiGeorge syndrome critical region gene 14; DiGeorge syndrome critical region gene DGSI
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96DF8
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表达区间
1-395aa
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氨基酸序列
MLGACFPNLSSGDVMVFGPGGLGQPVLHPVLVLGHHQQPVLGFGSKLVVGPVVGPQACLGVQFALSAVLALPLPLEGGRRRGFGLGGLQPRVAEDLIDVEPLADVGLQHAVDEVLALAGQVLGAREVHTVLLLDTQHLPDVGVVIGHGAADHDVQDHAQAPDVIHLGLVGDALQHLGGCICCRPAEGLAEDDAPIAVPQAALGEAKVRQLDVEVLVEEKVLALEVPVDDVQVVAVLDGGGELSEHLACHVLMQGSLALDELEKRLAPLPSTSPRHVGQQALSSFTLPEASGWAALGWASTQGWDTQHCLRVTSANELIKPRSGGGDWAEGEQGLWNRGSQAGLAGAPTPRPLEGSLSPGQDSGGPAAAALVSLSQVKLEGRRPTSSLFASPGCGD
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分子量
67 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DGCR14, a member of the DiGeorge syndrome critical region gene 14 family, has garnered attention due to its role in cellular processes and its potential implications in various diseases. Initially identified in the context of DiGeorge syndrome, a genetic disorder characterized by thymic, parathyroid, and cardiac anomalies, DGCR14 is located within a chromosomal region frequently deleted in this syndrome. Recent studies have revealed that DGCR14 is involved in critical biological functions, including immune system modulation and cellular signaling pathways, particularly those related to development and differentiation. The protein has been shown to interact with numerous cellular partners, suggesting its importance in complex molecular networks. Furthermore, aberrations in DGCR14 expression or function have been linked to disorders such as cancer and other developmental anomalies, highlighting the need for a comprehensive understanding of its biological roles. As a result, research has increasingly focused on the recombinant production of DGCR14 to study its structure and function in detail. This recombinant protein serves as a valuable tool for exploring its interactions and mechanisms, potentially paving the way for therapeutic strategies targeting diseases associated with DGCR14 dysregulation. Understanding the specifics of DGCR14’s role in health and disease could significantly advance our knowledge of genetic disorders and contribute to the development of novel interventions.
