Analytical Data
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基因名
DCAF16
- Application
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别名
DCAF16；C4orf30；DDB1- and CUL4-associated factor 16
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
C4orf30
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表达区间
1-216aa
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氨基酸序列
MGPRNPSPDHLSESESEEEENISYLNESSGEEWDSSEEEDSMVPNLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGALQFATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVNKLLTASL
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分子量
55.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCAF16, a member of the DCAFs (DDB1-CUL4-associated factor) family, plays a crucial role in ubiquitin-proteasome pathways, which are essential for regulating protein degradation and turnover in cells. Studies have shown that DCAF16 is involved in the recognition of substrate proteins by the E3 ubiquitin ligase complex, thereby influencing various cellular processes, including cell cycle regulation, DNA repair, and responses to stress. Recent research has highlighted the potential link between DCAF16 and cellular signaling pathways, particularly in the context of cancer biology, where dysregulation of ubiquitination can lead to tumor progression and resistance to therapies. Therefore, the recombinant expression of DCAF16 protein has become a focus of study to elucidate its functional mechanisms and interactions at the molecular level. By generating and characterizing this protein, researchers aim to advance our understanding of its role in cellular homeostasis and its potential as a therapeutic target. Additionally, investigating DCAF16 may provide insights into the broader implications of the ubiquitin-proteasome system in health and disease, making it a subject of significant interest in molecular and cellular biology.
