Analytical Data
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基因名
HPF1
- Application
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别名
HPF1；C4orf27；Histone PARylation factor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NWY4
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表达区间
1-346aa
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氨基酸序列
MVGGGGKRRPGGEGPQCEKTTDVKKSKFCEADVSSDLRKEVENHYKLSLPEDFYHFWKFCEELDPEKPSDSLSASLGLQLVGPYDILAGKHKTKKKSTGLNFNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDEFPVYVGINEAKKNCIIVPNGDNVFAAVKLFLTKKLREITDKKKINLLKNIDEKLTEAARELGYSLEQRTVKMKQRDKKVVTKTFHGAGLVVPVDKNDVGYRELPETDADLKRICKTIVEAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRNLFAEIIEEHLANRSQENIDQLAA
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分子量
59.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HPF1 (Histone Parafusin 1) is a crucial protein that has garnered significant attention in the field of molecular biology due to its role in mediating histone modifications and influencing chromatin dynamics. Research has shown that HPF1 is involved in the regulation of histone methylation and acetylation, processes essential for gene expression, DNA repair, and overall genomic stability. Its interactions with various histone modifying enzymes suggest that HPF1 might act as an important coordinator in chromatin remodeling, which is vital for cellular processes such as differentiation and response to environmental signals. Given the therapeutic implications of altered chromatin dynamics in diseases, including cancer, understanding the structure and function of HPF1 could provide insights into novel treatment strategies. Recent studies utilizing recombinant HPF1 protein have facilitated the exploration of its functional mechanisms, revealing potential targets for drug development. As a result, HPF1 is not only a fundamental research subject in epigenetics but also a promising candidate for future therapeutic interventions aimed at restoring normal chromatin function in diseased cells.
