Analytical Data
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Gene name
SNX27
- Application
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Alternative Names
KIAA0488; Methamphetamine responsive transcript 1; MGC126871; MGC126873; MGC20471; MRT1; MY014; OTTHUMP00000042487; RP11-98D18.12; SNX27; SNX27_HUMAN; Sorting nexin family member 27; Sorting nexin-27
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96L92
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Expression Region
1-541 aa
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AA Sequence
MADEDGEGIH PSAPHRNGGG GGGGGSGLHC AGNGGGGGGG PRVVRIVKSE SGYGFNVRGQ VSEGGQLRSI NGELYAPLQH VSAVLPGGAA DRAGVRKGDR ILEVNHVNVE GATHKQVVDL IRAGEKELIL TVLSVPPHEA DNLDPSDDSL GQSFYDYTEK QAVPISVPRY KHVEQNGEKF VVYNVYMAGR QLCSKRYREF AILHQNLKRE FANFTFPRLP GKWPFSLSEQ QLDARRRGLE EYLEKVCSIR VIGESDIMQE FLSESDENYN GVSDVELRVA LPDGTTVTVR VKKNSTTDQV YQAIAAKVGM DSTTVNYFAL FEVISHSFVR KLAPNEFPHK LYIQNYTSAV PGTCLTIRKW LFTTEEEILL NDNDLAVTYF FHQAVDDVKK GYIKAEEKSY QLQKLYEQRK MVMYLNMLRT CEGYNEIIFP HCACDSRRKG HVITAISITH FKLHACTEEG QLENQVIAFE WDEMQRWDTD EEGMAFCFEY ARGEKKPRWV KIFTPYFNYM HECFERVFCE LKWRKENIFQ MARSQQRDVA T
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Molecular Weight
61.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SNX27 (Sorting Nexin 27) is a member of the sorting nexin family, which plays a critical role in the intracellular trafficking of membrane proteins. This protein is known for its involvement in the endosomal recycling pathway, particularly in the recycling of G-protein coupled receptors (GPCRs) and other membrane proteins back to the plasma membrane. Research surrounding SNX27 has gained momentum due to its potential implications in various physiological and pathological processes, including neurodegenerative diseases, cancer progression, and metabolic disorders. Recent studies have focused on understanding the molecular mechanisms by which SNX27 interacts with its binding partners and influences their cellular localization and function. Additionally, the generation of recombinant SNX27 protein has enabled researchers to dissect its structural properties, functional domains, and the precise molecular interactions it engages in. This research is crucial for identifying potential therapeutic targets, as dysregulation of SNX27 and its pathway has been linked with significant disease states. As such, the production and characterization of recombinant SNX27 not only facilitate fundamental biological studies but also pave the way for developing novel intervention strategies aimed at modulating the trafficking of membrane proteins implicated in various diseases.
