Analytical Data
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Gene name
GNL3L
- Application
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Alternative Names
GNL3L；Guanine nucleotide-binding Protein-like 3-like Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NVN8
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Expression Region
1-582aa
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AA Sequence
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
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Molecular Weight
81.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GNL3L, or G protein nucleolar 3-like protein, is a highly conserved protein involved in various cellular processes, including ribosome biogenesis, cell proliferation, and the regulation of gene expression. Its significance emerged from research demonstrating its role in nucleolar function and assembly, where it facilitates the processing and maturation of rRNA. Recent studies have implicated GNL3L in the pathogenesis of several diseases, particularly cancer, where its overexpression correlates with tumor progression and poor prognosis. The necessity to explore GNL3L's functional mechanisms has propelled researchers to produce recombinant GNL3L proteins for in-depth biochemical and structural studies. By generating these proteins through recombinant DNA technology, scientists can investigate GNL3L's interactions with other nucleolar components and its involvement in cellular stress responses. This research aims not only to elucidate the functional dynamics of GNL3L but also to identify potential therapeutic targets for diseases associated with its dysregulation. With the availability of recombinant GNL3L, advances in understanding its precise roles at the molecular level are anticipated, paving the way for novel interventions in conditions where GNL3L function is compromised.
