Analytical Data
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Gene name
SNRP70
- Application
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Alternative Names
SNRNP70; RNPU1Z; RPU1; SNRP70; U1AP1U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; snRNP70
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08621
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Expression Region
1-210 aa
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AA Sequence
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRH
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Molecular Weight
28.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SNRP70 is a nuclear ribonucleoprotein essential for the splicing of pre-mRNA, playing a critical role in the post-transcriptional regulation of gene expression. It is part of the spliceosome complex, which is responsible for the precise removal of introns from pre-mRNA. The study of SNRP70 recombinant protein has garnered attention due to its potential implications in various biological processes and diseases. Dysregulation of splicing factors, including SNRP70, is implicated in several disorders, such as cancer and neurodegenerative diseases, highlighting the importance of understanding its function and mechanisms. The recombinant expression of SNRP70 enables researchers to investigate its structural properties, interactions with other spliceosomal components, and effects on splicing efficiency in vitro. Additionally, by producing this protein in a recombinant form, scientists can examine its role in cellular processes and potentially identify targets for therapeutic interventions. The exploration of SNRP70 not only enhances our understanding of RNA processing but also reveals insights into the intricacies of gene regulation and the development of novel strategies for treating diseases linked to splicing abnormalities.
