Analytical Data
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Gene name
SNRK
- Application
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Alternative Names
DKFZp779A1866; FLJ20224; HSNFRK; KIAA0096; SNF related kinase; SNF related serine/threonine protein kinase; SNF-related serine/threonine-protein kinase; SNF1 related kinase; SNF1-related kinase; SNFRK; Snrk; SNRK_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRH2
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Expression Region
1-765 aa
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AA Sequence
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPSHVSK ECKDLITRML QRDPKRRASL EEIENHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAADSVLN GHRSKGLCDS AKKDDLPELA GPALSTVPPA SLKPTASGRK CLFRVEEDEE EDEEDKKPMS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES RRRLDKDSGF TYSWHRRDSS EGPPGSEGDG GGQSKPSNAS GGVDKASPSE NNAGGGSPSS GSGGNPTNTS GTTRRCAGPS NSMQLASRSA GELVESLKLM SLCLGSQLHG STKYIIDPQN GLSFSSVKVQ EKSTWKMCIS STGNAGQVPA VGGIKFFSDH MADTTTELER IKSKNLKNNV LQLPLCEKTI SVNIQRNPKE GLLCASSPAS CCHVI
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Molecular Weight
84.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SNRK (Sperm Nucleus Remodelling Kinase) is a crucial protein kinase implicated in the regulation of sperm nucleus remodeling during fertilization. The significance of SNRK has gained attention due to its unique role in male fertility and its potential implications for reproductive health. Research indicates that SNRK is involved in various cellular processes, including cell cycle regulation and signal transduction, highlighting its multifaceted functions. Deficiencies or mutations in the SNRK gene may lead to reproductive challenges, making it a pertinent subject of investigation in the field of andrology and reproductive biology. Moreover, understanding the molecular mechanisms underlying SNRK's activities can provide insights into the broader signaling pathways involved in gametogenesis and early embryonic development. Recent studies have employed advanced techniques such as CRISPR-Cas9 gene editing and RNA sequencing to elucidate the specific roles of SNRK in spermatogenesis and its potential interactions with other fertility-related proteins. As reproductive issues continue to rise globally, the exploration of SNRK's functions could pave the way for novel approaches in diagnosing and treating male infertility, potentially offering new therapeutic targets for those affected by conditions related to compromised sperm function. Overall, the ongoing research into SNRK and its mechanisms reflects a vital intersection of cell biology, reproductive health, and molecular genetics, emphasizing the need for further exploration in this critical area of study.
