Cat: PA1000-7799

Recombinant Human NKAP Protein,His

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Analytical Data

  • Gene name

    NKAP

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    NKAP;NF-kappa-B-activating Protein

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8N5F7

  • Expression Region

    1-415aa

  • AA Sequence

    MAPVSGSRSP DREASGSGGR RRSSSKSPKP SKSARSPRGR RSRSHSCSRS GDRNGLTHQL GGLSQGSRNQ SYRSRSRSRS RERPSAPRGI PFASASSSVY YGSYSRPYGS DKPWPSLLDK EREESLRQKR LSERERIGEL GAPEVWGLSP KNPEPDSDEH TPVEDEEPKK STTSASTSEE EKKKKSSRSK ERSKKRRKKK SSKRKHKKYS EDSDSDSDSE TDSSDEDNKR RAKKAKKKEK KKKHRSKKYK KKRSKKSRKE SSDSSSKESQ EEFLENPWKD RTKAEEPSDL IGPEAPKTLT SQDDKPLNYG HALLPGEGAA MAEYVKAGKR IPRRGEIGLT SEEIASFECS GYVMSGSRHR RMEAVRLRKE NQIYSADEKR ALASFNQEER RKRENKILAS FREMVYRKTK GKDDK

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

NKAP (Nuclear KAP) proteins play a pivotal role in various biological processes, including gene regulation, cell differentiation, and immune responses. Recent studies have highlighted NKAP's involvement in the development of immune cells and its potential implications in autoimmune diseases and cancer. NKAP functions primarily as a co-regulator in transcriptional activation, influencing the expression of target genes crucial for T cell development and function. Additionally, abnormal NKAP expression has been linked to various pathological conditions, making it a target of interest for therapeutic interventions. The research surrounding NKAP recombinant proteins focuses on elucidating their structural and functional properties, providing insights into their molecular mechanisms and interactions within the cell nucleus. Understanding these aspects can lead to the identification of novel biomarkers for disease diagnosis and the development of targeted therapies. Moreover, through the study of NKAP recombinant proteins, researchers aim to unravel the complex regulatory networks involved in T cell biology, contributing to the broader field of immunology and the quest for effective treatments for immune-related disorders. This comprehensive approach underscores the significance of NKAP in both fundamental research and its potential clinical applications, paving the way for innovative strategies in immunotherapy and precision medicine.

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