Analytical Data
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Gene name
DCC1
- Application
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Alternative Names
DCC1 ; DCC1_HUMAN; Defective in sister chromatid cohesion 1 homolog; Defective in sister chromatid cohesion protein 1 homolog; DSCC1; hDCC1 ; MGC5528; Sister chromatid cohesion protein DCC1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVC3
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Expression Region
1-393aa
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AA Sequence
MKRTRDEVDATLQIAKLNAAELLPAVHCLGFGPGASGAAAGDFCLLELEPTLCQQLEDGHSLVIRGDKDEQAVLCSKDKTYDLKIADTSNMLLFIPGCKTPDQLKKEDSHCNIIHTEIFGFSNNYWELRRRRPKLKKLKKLLMENPYEGPDSQKEKDSNSSKYTTEDLLDQIQASEEEIMTQLQVLNACKIGGYWRILEFDYEMKLLNHVTQLVDSESWSFGKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYVDEGEVYFELDADKICRAAARMLLQNAVKFNLAEFQEVWQQSVPEGMVTSLDQLKGLALVDRHSRPEIIFLLKVDDLPEDNQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYSRSSMQNGVKVYNSRRPIS
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Molecular Weight
68.97 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DCC1, or Deleted in Colorectal Carcinoma 1, is a protein that has garnered attention due to its potential role in cancer biology, particularly in colorectal cancer. This protein is part of the immunoglobulin superfamily and is known to function as a receptor that can influence cellular adhesion, migration, and signaling pathways. Research has indicated that DCC1 is often downregulated or lost in various tumors, suggesting its involvement in tumor suppressor activity. Studies have also suggested that the interaction of DCC1 with several ligands may play crucial roles in neuronal development and may relate to the processes underlying cancer progression. Understanding the molecular mechanisms governing DCC1 expression and function could shed light on its role in tumorigenesis and might reveal novel targets for therapeutic intervention. As the field continues to explore the potential of DCC1 in cancer diagnostics and treatment, the protein's implications in cellular processes have made it a subject of significant interest among cancer researchers, prompting further investigation into its pathways and therapeutic potential.
