Analytical Data
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Gene name
SNAPC2
- Application
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Alternative Names
SNAPC2; SNAP45; snRNA-activating protein complex subunit 2; SNAPc subunit 2; Proximal sequence element-binding transcription factor subunit delta; PSE-binding factor subunit delta; PTF subunit delta; Small nuclear RNA-activating complex polypeptide 2; snRNA-activating protein complex 45 kDa subunit; SNAPc 45 kDa subunit
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13487
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Expression Region
1-334 aa
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AA Sequence
MKPPPRRR PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV AFSQVLTI TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APPSSAPR TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSES AVVLDLLMSL PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPE GDGAGSKAPE ETPPATEKAE HSELKSPWQA AGICPLNPFL VPLELLGR TPAR
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Molecular Weight
35.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNAPC2, a crucial component of the SNAPC (small nuclear RNA-activating protein complex) family, plays an essential role in the transcription of small nuclear RNAs, particularly U6 snRNA, which is vital for pre-mRNA splicing. The protein is composed of multiple domains that facilitate its interaction with other splicing factors and RNA polymerase II, ensuring efficient transcriptional regulation. Research over the years has indicated that SNAPC2 is not only critical for proper snRNA gene expression but also has implications in cell cycle regulation and cell differentiation. Abnormalities in SNAPC2 expression and function have been linked to various diseases, including certain cancers, where altered RNA splicing patterns may contribute to malignancy. Furthermore, the investigation of SNAPC2’s structure and function aids in understanding the molecular mechanisms underlying RNA processing and its diverse regulatory roles in cellular homeostasis. Consequently, studies focusing on the recombinant expression and functional characterization of SNAPC2 are essential for elucidating its biological significance and potential as a therapeutic target in RNA-related pathologies.
