Analytical Data
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基因名
GATA3
- Application
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别名
GATA3；Trans-acting T-cell-specific transcription factor GATA-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23771
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表达区间
2-443aa
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氨基酸序列
MASMTGGQQMGRGHHHHHHENLYFQGEVTADQPRWVSHHHPAVLNGQHPD THHPGLSHSYMDAA QYPLPEEVDVLFNIDGQGNHVPPYYGNSVRATVQ RYPPTHHGSQVCRPPLLHGSLPWLDGGKAL GSHHTASPWNLSPFSKTS IHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSL ST PGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPI TTYPPYVPEYSS GLFPPSSLLGGSPTGFGCKSRPKARSSTGRECVNCG ATSTPLWRRDGTGHYLCNACGLYHKMNG QNRPLIKPKRRLSAARRAGT SCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKE GIQT RNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSS HMLTTPTPMH PPSSLSFGPHHPSSMVTAMG
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分子量
51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GATA3 is a transcription factor that plays a crucial role in various biological processes, including T-cell development, immune response, and mammary gland differentiation. It is a member of the GATA family of zinc-finger proteins and is primarily expressed in T cells and epithelial tissues. Research has indicated that GATA3 is vital for the differentiation of Th2 cells and is implicated in the pathogenesis of several diseases, including allergies and certain types of cancer, particularly breast cancer. The GATA3 protein is frequently studied in the context of its regulatory functions, including its role as an oncogene in tumor progression. The recombinant GATA3 protein is produced through methods such as bacterial or cell-free expression systems, allowing for extensive biophysical characterization and functional assays. Such studies facilitate the understanding of GATA3’s structural properties and its interaction with DNA and other regulatory proteins. By investigating the function and dynamics of GATA3 through recombinant techniques, researchers aim to delineate its precise roles in cellular signaling pathways and to explore its potential as a therapeutic target in conditions like autoimmune diseases and cancer.
