Analytical Data
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Gene name
SLC9A6
- Application
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Alternative Names
3732426M05; 6430520C02Rik; KIAA0267; mKIAA0267; MRSA; Na(+)/H(+) exchanger 6; NHE-6; NHE6; OTTHUMP00000024089; OTTHUMP00000024090; RGD1563582; RP11-274K13.1; RP23-105E2.4; SL9A6_HUMAN; SLC9A6; Sodium/hydrogen exchanger 6; Solute carrier family 9 (sodium/hydrogen exchanger); isoform 6; Solute carrier family 9 (sodium/hydrogen exchanger); member 6; Solute carrier family 9 member 6; solute carrier family 9; subfamily A (NHE6; cation proton antiporter 6); member 6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92581
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Expression Region
1-701 aa
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AA Sequence
MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
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Molecular Weight
104.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC9A6, a member of the solute carrier family 9, encodes a sodium/hydrogen exchanger primarily expressed in the brain. Mutations in the SLC9A6 gene have been linked to X-linked intellectual disability, characterized by developmental delays and impaired cognitive function. The study of SLC9A6 recombinant protein is crucial for understanding its physiological role and the molecular mechanisms underlying the associated disorders. Research has demonstrated that SLC9A6 plays a vital role in intracellular pH regulation, protein trafficking, and endosomal function, all of which are essential for neuronal health and function. Investigating its structure and function through recombinant protein techniques allows for insights into its transport mechanisms and interactions with various cellular components. Moreover, understanding the impact of specific mutations on the protein's functionality can help in developing therapeutic strategies for related neurodevelopmental disorders. Given the increasing prevalence of intellectual disabilities and the complexity of their genetic underpinnings, SLC9A6 recombinant protein studies represent an important frontier in biomedical research, potentially leading to innovative treatments and interventions for affected individuals.
