Analytical Data
-
Gene name
SLC7A8
- Application
-
Alternative Names
hLAT2; integral membrane protein E16H; L type amino acid transporter 2; L-type amino acid transporter 2; Large neutral amino acids transporter small subunit 2; LAT2_HUMAN; LPI PC1; SLC7A8; solute carrier family 7 (amino acid transporter light chain; L system); member 8; solute carrier family 7 (amino acid transporter; L type); member 8; solute carrier family 7 (cationic amino acid transporter; y+ system); member 8; Solute carrier family 7 member 8
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UHI5
-
Expression Region
1-535 aa
-
AA Sequence
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
-
Molecular Weight
84.8 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC7A8, also known as LAT2, is a member of the solute carrier family of transporters that plays a critical role in the transport of neutral amino acids across cell membranes. It is primarily expressed in various tissues, including the intestine, kidney, and brain, suggesting its involvement in essential physiological processes such as nutrient absorption and neurotransmitter synthesis. Research has identified SLC7A8 as a potential contributor to various pathophysiological conditions, including cancer, where altered amino acid transport can influence tumor growth and metastasis. Additionally, its role in metabolic disorders has garnered interest, as dysregulated amino acid levels are linked to insulin resistance and obesity. Due to its significant implications in both normal physiology and disease states, SLC7A8 has emerged as a target for therapeutic interventions. The production and characterization of recombinant SLC7A8 protein are crucial for elucidating its structure-function relationships and understanding its transport mechanisms at the molecular level. Furthermore, studies involving SLC7A8 may provide insights into potential drug development strategies aimed at modulating amino acid transport to combat various diseases. In summary, research on SLC7A8 recombinant protein is pivotal for advancing our knowledge of amino acid transport and its broader implications in health and disease.
