Analytical Data
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基因名
SLC4A1AP
- Application
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别名
FLJ10624; FLJ41004; HLC-3; HLC3; Human lung cancer oncogene 3 protein; Kanadaptin; Kidney anion exchanger adapter protein; Kidney anion exchanger adaptor protein; Lung cancer oncogene 3 protein; MGC120646; MGC120648 ; NADAP_HUMAN; SLC4A1AP; Solute carrier family 4 (anion exchanger) member 1 adaptor protein; Solute carrier family 4 anion exchanger member 1 adapter protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BWU0
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表达区间
1-796 aa
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氨基酸序列
MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL HRLRMADILS QSETLASQDL SGDFKKPALP VSPRSKAP ASSSSNPEEV QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEVQEM RPPTDLTHFK ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY
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分子量
82.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC4A1AP, or SLC4A1 adaptor protein, plays a crucial role in the regulation of bicarbonate transport, particularly in the context of the SLC4A1 (AE1) anion exchanger, which is vital for maintaining acid-base balance in various tissues, including red blood cells and kidneys. Research has revealed that SLC4A1AP functions as a scaffolding protein that facilitates the proper trafficking and recycling of AE1 to the plasma membrane, thus enhancing its activity. Mutations in the SLC4A1 gene, which encodes the AE1 protein, can lead to disorders such as hereditary xerocytosis and other hematological conditions. Consequently, understanding the structure and function of SLC4A1AP is essential for deciphering these pathologies. Recombinant protein studies have gained significant attention as they provide insights into the protein's interactions with AE1 and other cellular partners. Such investigations can pave the way for targeted therapeutic strategies, potentially alleviating conditions caused by impaired bicarbonate transport. As the field of molecular medicine advances, characterizing recombinant SLC4A1AP offers a promising avenue for understanding how disruptions in this protein's function contribute to disease, while also highlighting its potential as a biomarker or therapeutic target in conditions related to ion transport.
