Analytical Data
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Gene name
CXXC5
- Application
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Alternative Names
CF5; CXXC finger 5 protein; CXXC finger protein 5; CXXC-type zinc finger protein 5; CXXC5; CXXC5_HUMAN; HSPC195; Putative MAPK-activating protein PM08
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7LFL8
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Expression Region
1-322aa
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AA Sequence
MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA DDTPPPERRN KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE SADKATAAAA AASLLANGHD LAAAMAVDKS NPTSKHKSGA VASLLSKAER ATELAAEGQL TLQQFAQSTE MLKRVVQEHL PLMSEAGAGL PDMEAVAGAE ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL AEYPMQGELA SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK KKPSAALEKV MLPTGAAFRW FQ
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Molecular Weight
32.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXXC5, a member of the CXXC-type zinc finger protein family, has garnered significant interest due to its potential roles in various biological processes and pathological conditions. Research indicates that CXXC5 is involved in regulating Wnt signaling pathways, which are crucial for cell proliferation, differentiation, and development. Abnormalities in Wnt signaling have been implicated in various diseases, including cancer, making CXXC5 a protein of interest for therapeutic interventions. Additionally, studies suggest that CXXC5 may act as a tumor suppressor by modulating the expression of target genes linked to cellular growth and apoptosis. Reconstituting CXXC5 as a recombinant protein allows for in-depth investigations of its structural and functional properties, providing insights into its mechanism of action. Understanding the functional dynamics of CXXC5 could pave the way for novel treatment strategies, especially in cancers where Wnt pathway dysregulation is prevalent. Moreover, exploring its interactions with other proteins and cellular pathways can enhance our understanding of its role in physiology and disease, highlighting the importance of CXXC5 in biomedical research. This research is crucial not only for elucidating the fundamental biology of CXXC5 but also for identifying potential clinical applications in targeted therapies.
