Analytical Data
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Gene name
SLC40A1
- Application
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Alternative Names
Ferroportin 1; Ferroportin; Ferroportin-1; FPN1; HFE4; IREG1; iron regulated gene 1; Iron regulated transporter 1 ; Iron-regulated transporter 1; MST079; MSTP079; MTP1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; S40A1_HUMAN; SLC11A3; SLC11A3; formerly; SLC40A1; solute carrier family 11 (proton-coupled divalent metal ion transporters); member 3; solute carrier family 11 (proton-coupled divalent metal ion transporters); member 3; formerly; solute carrier family 40 (iron-regulated transporter); member 1; Solute carrier family 40 member 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NP59
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Expression Region
1-571 aa
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AA Sequence
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
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Molecular Weight
88.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC40A1, also known as ferroportin, is a key protein involved in iron homeostasis within the human body. It plays a crucial role in the export of non-heme iron from cells into the bloodstream, thus regulating systemic iron levels. Dysregulation of SLC40A1 is associated with various iron-related disorders, including hereditary hemochromatosis and iron-refractory iron deficiency anemia, making it a significant focus of biomedical research. The recombinant production of SLC40A1 has emerged as a vital tool for studying its structure-function relationship, mechanisms of iron transport, and potential interactions with other proteins or small molecules. By generating SLC40A1 in a controlled laboratory setting, researchers can investigate the protein's biochemical properties and functional dynamics, enabling a deeper understanding of its role in iron metabolism. Additionally, recombinant SLC40A1 is instrumental in the development of therapeutic strategies targeting iron overload conditions. Overall, the study of SLC40A1 and its recombinant variants is fundamental for advancing knowledge in iron biology and addressing related diseases.
