Analytical Data
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Gene name
SRP9
- Application
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Alternative Names
SRP9；Signal recognition particle 9 kDa Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49458
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Expression Region
2-86aa
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AA Sequence
PQYQTWEEF SRAAEKLYLA DPMKARVVLK YRHSDGNLCV KVTDDLVCLV YKTDQAQDVK KIEKFHSQLM RLMVAKEARN VTMETE
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SRP9, a member of the signal recognition particle (SRP) complex, plays a vital role in the co-translational translocation of proteins across the endoplasmic reticulum membrane in eukaryotic cells. This protein is crucial for targeting nascent polypeptides that possess signal peptides to the endoplasmic reticulum, facilitating proper protein maturation and secretion. Recent studies have highlighted the importance of SRP9 in influencing the efficiency and fidelity of protein synthesis and translocation, with implications for various cellular functions and pathways. Research has indicated that dysfunction in SRP components, including SRP9, can lead to a range of diseases, underscoring its significance in cellular homeostasis. Furthermore, the characterization of recombinant SRP9 can provide insights into its structural and functional properties, potentially aiding in the development of therapeutic approaches for conditions stemming from protein trafficking errors. Understanding the molecular mechanisms involving SRP9 is essential, as it expands our comprehension of the cellular machinery and may unveil novel targets for drug discovery in the realm of protein misfolding diseases and related disorders.
