Analytical Data
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Gene name
GALNT14
- Application
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Alternative Names
GALNT14；Polypeptide N-acetylgalactosaminyltransferase 14
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FL9
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Expression Region
1-552aa
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AA Sequence
MRRLTRRLVLPVFGVLWITVLLFFWVTKRKLEVPTGPEVQTPKPSDADWDDLWDQFDERRYLNAKKWRVGDDPYKLYAFNQRESERISSNRAIPDTRHLRCTLLVYCTDLPPTSIIITFHNEARSTLLRTIRSVLNRTPTHLIREIILVDDFSNDPDDCKQLIKLPKVKCLRNNERQGLVRSRIRGADIAQGTTLTFLDSHCEVNRDWLQPLLHRVKEDYTRVVCPVIDIINLDTFTYIESASELRGGFDWSLHFQWEQLSPEQKARRLDPTEPIRTPIIAGGLFVIDKAWFDYLGKYDMDMDIWGGENFEISFRVWMCGGSLEIVPCSRVGHVFRKKHPYVFPDGNANTYIKNTKRTAEVWMDEYKQYYYAARPFALERPFGNVESRLDLRKNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGEDAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQHWDMVSS
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Molecular Weight
71.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GALNT14, a member of the polypeptide N-acetylgalactosaminyltransferase family, plays a crucial role in the initiation of O-glycosylation, a vital post-translational modification influencing protein stability, function, and cell signaling. This enzyme transfers N-acetylgalactosamine (GalNAc) to serine or threonine residues on target proteins, impacting various physiological processes, such as cell adhesion, apoptosis, and immune responses. Recent studies have revealed that GALNT14 is involved in the progression of several cancers and diseases, making it a potential biomarker and therapeutic target. Its atypical expression patterns in tumor tissues compared to normal tissues underscore its significance in cancer pathology. Understanding the structure and function of GALNT14 through recombinant protein studies enables researchers to elucidate its mechanisms of action and explore its potential for therapeutic intervention. Consequently, the reconstitution of GALNT14 in a laboratory setting provides a valuable tool for investigating its enzymatic activity, substrate specificity, and interactions with other cellular components, ultimately contributing to the broader research into glycosylation-related diseases and therapeutic avenues.
