Analytical Data
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基因名
ABCG1
- Application
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别名
ABCG1；ABC8；WHT1；ATP-binding cassette sub-family G member 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P45844
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表达区间
1-426aa
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氨基酸序列
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLR
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分子量
51.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCG1 (ATP-binding cassette sub-family G member 1) is a crucial membrane transporter that plays a significant role in lipid homeostasis and cholesterol metabolism. This protein is primarily expressed in macrophages and other cell types, where it facilitates the efflux of excess cellular cholesterol and phospholipids, thereby preventing the accumulation of lipids that can lead to atherosclerosis and cardiovascular diseases. Research has increasingly focused on understanding the structure-function relationship of ABCG1 and its mechanism of action in lipid transport. Mutations or dysregulation of ABCG1 are associated with various metabolic disorders, highlighting the importance of this protein in maintaining cellular and systemic lipid balance. Furthermore, ABCG1 is implicated in the modulation of immune responses and inflammation, linking it to broader health implications beyond lipid metabolism. Given its critical functions, recombinant ABCG1 protein has become an essential tool in scientific studies aimed at elucidating its biological roles and potential therapeutic applications. Researchers are utilizing recombinant techniques to produce and purify ABCG1, enabling detailed experimental investigations into its transport mechanism, regulatory pathways, and interactions with other biomolecules. Understanding ABCG1's properties may provide insights into novel therapeutic strategies for managing dyslipidemia and related disorders, marking it as a key target for future biomedical research.
