Analytical Data
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基因名
SLC22A17
- Application
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别名
24p3 receptor; 24p3R; BOCT; BOIT; Brain type organic cation transporter; Brain-type organic cation transporter; hBOIT; Lipocalin-2 receptor; Neutrophil gelatinase associated lipocalin receptor; Neutrophil gelatinase-associated lipocalin receptor; NGAL receptor; NgalR; NGALR2; NGALR3; OTTHUMP00000082690; OTTHUMP00000082691; Potent brain type organic ion transporter; S22AH_HUMAN; Slc22a17; Solute carrier family 22 member 17; Solute carrier family 22 organic cation transporter member 17
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WUG5
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氨基酸序列
MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL
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分子量
59.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC22A17, a member of the solute carrier family, encodes a multi-specific organic cation transporter, which is primarily expressed in human tissues such as the kidney, liver, and brain. Its biological significance stems from its role in the uptake and transport of various organic ions and cationic drugs, influencing their pharmacokinetics and pharmacodynamics. Research on SLC22A17 is particularly relevant in understanding its implications in drug metabolism, elimination, and the transport of endogenous compounds, making it a potential target for therapeutic interventions. Recent studies have indicated that SLC22A17 may also play a role in the pathophysiology of certain diseases, including cancer and metabolic disorders, by affecting the availability of substrates for crucial metabolic pathways. The production of recombinant SLC22A17 protein is essential to elucidate its functional properties and regulatory mechanisms under physiological and pathological conditions. By generating this recombinant protein, researchers aim to investigate the transport characteristics, substrate specificity, and potential interactions with pharmaceutical compounds, ultimately contributing to a deeper understanding of its role in drug disposition and toxicity. The ongoing exploration of SLC22A17 is expected to provide valuable insights into its therapeutic potential and enhance the development of targeted drugs, ultimately improving treatment efficacy and safety profiles for various conditions.
