Analytical Data
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基因名
CREB3L4
- Application
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别名
1700012K17Rik; AIbZIP; Androgen induced basic leucine zipper; Androgen induced basic leucine zipper protein; Androgen-induced basic leucine zipper protein; ATCE1; Attaching to CRE like 1; Attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 3 like 4; cAMP responsive element binding protein 4; cAMP responsive element-binding protein 3 like protein 4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TEY5
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表达区间
1-395aa
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氨基酸序列
MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGLQESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTTLLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPPGAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
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分子量
69.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CREB3L4, a member of the CREB/ATF family of transcription factors, has garnered increasing attention in recent years due to its pivotal role in cellular stress responses and various physiological processes. This protein is primarily localized in the endoplasmic reticulum (ER) and functions as a sensor for ER stress, regulating the UPR (unfolded protein response) to maintain cellular homeostasis. Dysregulation of CREB3L4 has been implicated in numerous diseases, including cancers and neurodegenerative disorders. Its involvement in promoting cell survival under stress conditions makes it a potential target for therapeutic interventions. Research has focused on understanding the mechanistic pathways mediated by CREB3L4, including its interactions with other molecular players in the UPR and its transcriptional targets that govern cell fate. Additionally, studies are exploring the structural aspects of the CREB3L4 protein, as detailed knowledge of its conformation and functional domains can illuminate its regulatory mechanisms. The recombinant expression of CREB3L4 not only facilitates the study of its biochemical properties but also aids in identifying novel ligands or inhibitors that could modulate its activity. As ongoing investigations delve into its roles in health and disease, CREB3L4 continues to emerge as a promising candidate for further exploration in the field of molecular biology and therapeutic development.
