Analytical Data
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Gene name
SLC17A3
- Application
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Alternative Names
SLC17A3; NPT4; Sodium-dependent phosphate transport protein 4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00476
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Expression Region
1-420 aa
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AA Sequence
MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPTKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
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Molecular Weight
72.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC17A3, part of the SLC17 (solute carrier 17) family, encodes a sodium-dependent inorganic phosphate transporter crucial for various physiological processes in human cells. It plays a significant role in renal phosphate handling and is implicated in disorders related to phosphate homeostasis, such as familial tumoral calcinosis and hypophosphatemic rickets. The protein's ability to transport phosphates across cell membranes is essential for cellular metabolism, bone mineralization, and overall phosphate balance in the body. Given its pivotal role, research on SLC17A3 is focused on understanding its structure-function relationship, regulatory mechanisms, and potential therapeutic targets. Recombinant SLC17A3 protein is increasingly being produced for functional studies, allowing researchers to elucidate its transport kinetics, interaction with specific substrates, and the impact of genetic mutations on its functionality. Such studies are vital for developing targeted treatments for related disorders and broadening our understanding of phosphate transport mechanisms in health and disease. Through advances in recombinant protein technology, SLC17A3 research continues to pave the way for innovations in treating phosphate-related diseases.
