Analytical Data
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Gene name
CPNE8
- Application
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Alternative Names
Copine 8; Copine VIII; Copine-8; CPNE8; CPNE8_HUMAN; MGC129645; MGC129646
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86YQ8
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Expression Region
1-564aa
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AA Sequence
MDSRYNSTAGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNGNPAQPTSPHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVKDGSQYFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSRGKYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPYTPPTHVLQTQI
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Molecular Weight
88.44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CPNE8, or Copine 8, is a member of the copine family of proteins characterized by the presence of C2 and ankyrin repeat domains, which play crucial roles in cellular processes such as membrane trafficking, signal transduction, and cell adhesion. Recent studies have suggested that CPNE8 is involved in various physiological and pathological conditions, including cancer progression and neurodegenerative diseases. The protein's ability to bind calcium ions and interact with phospholipid membranes highlights its potential as a regulator in signaling pathways. Understanding CPNE8's structural and functional properties through recombinant protein studies is essential in elucidating its role in cellular mechanisms. Recombinant CPNE8 can be produced in various expression systems, allowing for detailed biochemical and biophysical characterization. This research aims to uncover the protein's interaction partners and its specific functions within cellular contexts, providing insights into its contribution to diseases and opening avenues for therapeutic interventions. The demand for targeted protein studies, particularly regarding CPNE8's implications in disease, underscores the importance of developing reliable methods for its expression and purification. Exploring CPNE8 at the molecular level may reveal novel targets for drug design and therapeutic strategies, highlighting the significance of this research in the broader landscape of molecular biology and medicine.
