Analytical Data
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基因名
COX8A
- Application
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别名
COX; COX8; COX8-2; COX8A; COX8A_HUMAN; COX8L; Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2; Cytochrome c oxidase subunit 8A (ubiquitous); Cytochrome c oxidase subunit 8A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10176
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表达区间
1-69aa
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氨基酸序列
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILSHLETYRRPE
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分子量
34 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The COX8A gene encodes a subunit of cytochrome c oxidase, which is a crucial component of the mitochondrial respiratory chain, playing a pivotal role in cellular energy production through oxidative phosphorylation. Research on COX8A has garnered attention due to its implications in various metabolic disorders and mitochondrial diseases, where altered mitochondrial function can lead to a range of clinical manifestations. Understanding the structure and function of the COX8A protein is essential for elucidating its role in electron transport and energy metabolism. Recombinant COX8A protein has been generated to facilitate in vitro studies, allowing researchers to investigate its biochemical properties, interaction with other mitochondrial components, and potential regulatory mechanisms. Additionally, exploring variants of COX8A may provide insights into genetic predispositions to mitochondrial dysfunction and associated diseases. Overall, studying COX8A through recombinant protein techniques not only enhances our fundamental knowledge of mitochondrial biology but also paves the way for potential therapeutic strategies targeting mitochondrial-related diseases.
