Analytical Data
-
Gene name
SLC10A2
- Application
-
Alternative Names
Apical sodium-dependent bile acid transporter;ASBT;Ileal sodium-dependent bile acid transporter;IBAT;ISBT;Na+;Sodium/taurocholate cotransporting polypeptide. ileal;Solute carrier family 10 member 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q12908
-
Expression Region
1-348 aa
-
AA Sequence
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
-
Molecular Weight
39.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC10A2, also known as the sodium-dependent bile acid transporter, is a critical membrane protein involved in the hepatic uptake of bile acids, which play essential roles in lipid metabolism and the regulation of cholesterol levels. Due to its significance in bile acid homeostasis and potential implications in various liver-related diseases, including cholestasis and liver cirrhosis, the study of SLC10A2 is gaining increasing attention. Its dysfunction is linked to impaired bile acid recycling and can contribute to metabolic disorders. The recombinant expression of SLC10A2 in suitable systems allows for the detailed characterization of its transport mechanisms, substrate specificity, and kinetic properties, thus providing insights into its physiological roles and potential therapeutic applications. Understanding the structural and functional aspects of SLC10A2 through recombinant proteins also offers opportunities for drug development targeting bile acid transport pathways. Overall, research on recombinant SLC10A2 not only enhances our comprehension of bile acid transport but also aids in the exploration of novel strategies for treating liver diseases associated with bile acid dysregulation.
