Analytical Data
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基因名
SLC10A2
- Application
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别名
Apical sodium-dependent bile acid transporter;ASBT;Ileal sodium-dependent bile acid transporter;IBAT;ISBT;Na+;Sodium/taurocholate cotransporting polypeptide. ileal;Solute carrier family 10 member 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12908
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表达区间
1-348 aa
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氨基酸序列
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
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分子量
39.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC10A2, also known as the sodium-dependent bile acid transporter, is a critical membrane protein involved in the hepatic uptake of bile acids, which play essential roles in lipid metabolism and the regulation of cholesterol levels. Due to its significance in bile acid homeostasis and potential implications in various liver-related diseases, including cholestasis and liver cirrhosis, the study of SLC10A2 is gaining increasing attention. Its dysfunction is linked to impaired bile acid recycling and can contribute to metabolic disorders. The recombinant expression of SLC10A2 in suitable systems allows for the detailed characterization of its transport mechanisms, substrate specificity, and kinetic properties, thus providing insights into its physiological roles and potential therapeutic applications. Understanding the structural and functional aspects of SLC10A2 through recombinant proteins also offers opportunities for drug development targeting bile acid transport pathways. Overall, research on recombinant SLC10A2 not only enhances our comprehension of bile acid transport but also aids in the exploration of novel strategies for treating liver diseases associated with bile acid dysregulation.
