Analytical Data
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Gene name
CSF1R
- Application
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Alternative Names
CSF1R；FMS；Macrophage colony-stimulating factor 1 receptor
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09581
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Expression Region
20-511aa
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AA Sequence
APVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTL TTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVE GQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKV LDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEA AQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVD FQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSL ILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRV KASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDV SGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQ LPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDES
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Molecular Weight
81 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSF1R (Colony Stimulating Factor 1 Receptor) is a vital receptor protein that plays a significant role in regulating the survival, proliferation, and differentiation of monocytes and macrophages, which are crucial components of the immune system. Dysregulation of CSF1R signaling has been implicated in various pathologies, including cancer, where tumor-associated macrophages can promote tumor growth and metastasis. Consequently, CSF1R has emerged as a promising target for therapeutic interventions. Researchers have been focusing on the characterization and development of recombinant CSF1R proteins to better understand its biological functions and to explore its potential as a drug target. The design of these recombinant proteins involves the use of advanced molecular biology techniques to produce functional proteins that can mimic natural CSF1R. These studies aim not only to elucidate the signaling pathways associated with CSF1R but also to assess the efficacy of novel inhibitors that could disrupt its function in tumor microenvironments. The ongoing research seeks to provide insights into how modulating CSF1R activity could enhance anti-tumor immune responses and lead to innovative treatments for various cancers, thereby highlighting the importance of CSF1R recombinant proteins in both basic and applied biomedical research.
