Analytical Data
-
Gene name
COX7A2
- Application
-
Alternative Names
COX7A2; COX7AL; COX7AL1; COXVIIa L; COXVIIAL; CX7A2_HUMAN; Cytochrome c oxidase polypeptide 7A2 mitochondrial; Cytochrome c oxidase polypeptide VIIa liver/heart; Cytochrome c oxidase subunit 7A2; Cytochrome c oxidase subunit 7A2 mitochondrial; Cytochrome c oxidase subunit VIIa polypeptide 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P14406
-
Expression Region
24-83aa
-
AA Sequence
FKNKVPE KQKLFQEDDE IPLYLKGGVA DALLYRATMI LTVGGTAYAI YELAVASFPK KQE
-
Molecular Weight
9.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
COX7A2, a key component of the cytochrome c oxidase (CCO) complex, plays a crucial role in mitochondrial bioenergetics by facilitating the final step of the electron transport chain in aerobic respiration. This protein is part of the hemoprotein family and is predominantly expressed in cardiac and skeletal muscles, where it is essential for ATP production. Recent studies have highlighted the significance of COX7A2 in various pathophysiological conditions, including heart diseases, neurological disorders, and metabolic syndromes, suggesting its potential as a biomarker or therapeutic target. The recombinant expression of COX7A2 provides a valuable tool for investigating its structure-function relationship, understanding its role in mitochondrial dynamics, and exploring its interactions with other subunits of the CCO complex. Additionally, characterizing this protein can enhance our understanding of mitochondrial dysfunctions and their implications in disease contexts. Given the ongoing interest in mitochondrial research and energy metabolism, studying COX7A2 through recombinant technology may contribute to the development of innovative therapeutic strategies aimed at improving mitochondrial function and treating related disorders.
