Analytical Data
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Gene name
AXL
- Application
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Alternative Names
AXL；UFO；Tyrosine-Protein kinase receptor UFO
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P30530
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Expression Region
473-894aa
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AA Sequence
HRRKKETRYGEVFEPTVERGELVVRYCVRKSYSRRTTEATLNSLGISEEL KEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIA ICTRSELEDFLSEAVCMKEF DHPNVMRLIGVCFQGSERESFPAPVVIL PFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIH RDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMP VKWIAI ESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL KQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDE ILYVNMDEGGGYPE PPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRY VLCPSTTPSPAQPADRGSPAAPGQEDGA
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Molecular Weight
76 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AXL is a receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell survival, proliferation, and migration. Its overexpression has been implicated in several types of cancer, making it a significant target for therapeutic intervention. Recent studies have highlighted the importance of AXL in mediating resistance to conventional therapies, particularly in malignancies such as breast cancer, lung cancer, and melanoma. The dysregulation of AXL signaling pathways not only contributes to tumorigenesis but also facilitates cancer progression and metastasis. Consequently, researchers have focused on the development of AXL recombinant proteins to better understand its biological functions and the mechanisms underlying its oncogenic properties. These recombinant proteins serve as vital tools for elucidating the molecular interactions of AXL with its ligands and downstream signaling pathways. By investigating AXL's structure and function through these proteins, scientists aim to identify potential biomarkers for cancer diagnosis and prognosis, as well as to explore novel therapeutic strategies, including AXL-targeted monoclonal antibodies and small molecule inhibitors. The ongoing research into AXL recombinant proteins is essential for advancing cancer treatment and improving patient outcomes in AXL-associated malignancies.
