Analytical Data
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基因名
COX4I2
- Application
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别名
AL024441; COX 4; COX IV 1; COX IV; COX IV-1; Cox4; COX41_HUMAN; Cox4a; COX4B; COX4I1; COX4I2; COX4L2; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial; Cytochrome c oxidase subunit 4 isoform 1. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13073
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表达区间
23-169aa
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氨基酸序列
AHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK
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分子量
33.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COX4I2 is a nuclear-encoded subunit of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial electron transport chain, which plays a critical role in cellular respiration and energy production. Research into COX4I2 has garnered interest due to its implications in various physiological and pathological processes. Unlike its counterpart COX4I1, COX4I2 is particularly expressed in various tissues and is thought to be involved in the adaptation of cells to fluctuating oxygen levels, a process crucial for maintaining cellular homeostasis and supporting metabolic demands. Studies have shown that COX4I2 expression can influence mitochondrial function, thereby affecting overall cellular energy metabolism and survival under stress conditions. Moreover, aberrations in COX4I2 expression have been linked to several diseases, including cancer and neurodegenerative disorders, highlighting its potential role as a biomarker or therapeutic target. Given its importance in mitochondrial bioenergetics and disease pathology, the recombinant expression and characterization of COX4I2 provide valuable insights into its structural properties and functional mechanisms. This research could facilitate the development of innovative strategies for therapeutic intervention in diseases associated with mitochondrial dysfunction, making COX4I2 a significant focus in contemporary biomedical research.
