Analytical Data
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Gene name
TNFRSF10D
- Application
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Alternative Names
TNFRSF10D；DCR2；TRAILR4；TRUNDD；Tumor necrosis factor receptor superfamily member 10D
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UBN6
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Expression Region
56-211aa
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AA Sequence
ATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDY TIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMC RTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGM LASPYHVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPE VTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTV LHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYS KLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNFRSF10D, also known as Decoy Receptor 3 (Dcr3), is a member of the tumor necrosis factor receptor superfamily and plays a pivotal role in modulating immune responses and promoting cell survival. This protein is primarily known for its ability to bind to ligands of the TNF superfamily, such as TRAIL (TNF-related apoptosis-inducing ligand), thereby inhibiting apoptosis in various cell types. Its significance has been underscored in the context of several diseases, including autoimmune disorders and cancers. Research has demonstrated that TNFRSF10D can regulate the tumor microenvironment, supporting cancer cell proliferation by neutralizing pro-apoptotic signals. Consequently, recombinant TNFRSF10D proteins have become valuable tools for studying its biological functions, therapeutic applications, and potential as a biomarker for disease progression. In addition, understanding its interaction with other signaling pathways could inform novel therapeutic strategies aimed at enhancing immune responses against tumors or alleviating inflammation in chronic diseases. Thus, the recombinant production and characterization of TNFRSF10D not only contribute to basic research but also hold promise for clinical applications, providing insights into the development of targeted therapies and improving patient outcomes.
