Analytical Data
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Gene name
MST4
- Application
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Alternative Names
MST4；MASK；MST4；Serine/threonine-Protein kinase 26
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P289
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Expression Region
1-416aa
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AA Sequence
MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV AIKIIDLEEA EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME YLGGGSALDL LRAGPFDEFQ IATMLKEILK GLDYLHSEKK IHRDIKAANV LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV IQQSAYDSKA DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLV GDFTKSFKEF IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS DDESDSEGSD SESTSRENNT HPEWSFTTVR KKPDPKKVQN GAEQDLVQTL SCLSMIITPA FAELKQQDEN NASRNQAIEE LEKSIAVAEA ACPGITDKMV KKLIEKFQKC SADESP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MST4, or Mammalian Ste20-like kinase 4, is a serine/threonine kinase belonging to the Ste20 family, which plays a crucial role in various cellular processes including cell growth, apoptosis, and cytokine signaling. Originally identified in the context of cellular signaling pathways, MST4 has garnered attention due to its involvement in the regulation of the Hippo pathway, a key signaling cascade that controls organ size and tissue homeostasis. Moreover, dysregulation of MST4 and the Hippo pathway has been linked to several diseases, including cancer and cardiovascular disorders. As a result, the recombinant expression of MST4 protein has become a focal point for research aimed at elucidating its functional roles in these disease states. Techniques such as molecular cloning and protein expression in various systems, including bacterial and mammalian cells, have enabled scientists to produce large quantities of purified MST4 protein. This facilitates structural and functional studies that aim to clarify its role in cellular signaling networks and potential therapeutic implications. Understanding MST4's molecular mechanisms not only provides insights into fundamental biological processes but also lays the groundwork for developing novel intervention strategies against diseases associated with its dysregulation.
