Analytical Data
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基因名
COQ4
- Application
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别名
Ubiquinone biosynthesis protein COQ4 homolog. mitochondrial. 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase. EC:4.1.1.-. Coenzyme Q biosynthesis protein 4 homolog
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y3A0
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表达区间
1-265aa
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氨基酸序列
MATLLRPVLRRLCGLPGLQRPAAEMPLRARSDGAGPLYSHHLPTSPLQKALLAAGSAAMALYNPYRHDMVAVLGETTGHRTLKVLRDQMRRDPEGAQILQERPRISTSTLDLGKLQSLPEGSLGREYLRFLDVNRVSPDTRAPTRFVDDEELAYVIQRYREVHDMLHTLLGMPTNILGEIVVKWFEAVQTGLPMCILGAFFGPIRLGAQSLQVLVSELIPWAVQNGRRAPCVLNLYYERRWEQSLRALREELGITAPPMHVQGLA
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分子量
56.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Coenzyme Q (CoQ) is an essential component of the electron transport chain, playing a critical role in cellular respiration and energy production. Among the various forms of CoQ, CoQ4 has garnered attention due to its involvement in various biological processes and potential implications in health and disease. Recent studies suggest that COQ4, a gene encoding a key enzyme in the biosynthesis of CoQ, is vital for proper mitochondrial function and could be linked to conditions such as neurodegenerative diseases and aging-related disorders. Given its importance, researchers have focused on the recombinant expression of COQ4 protein to better understand its structure, function, and interactions within the cell. By producing COQ4 in a recombinant system, scientists are able to study its enzymatic activity and character its role in CoQ biosynthesis. This research not only enhances the understanding of mitochondrial biology but also opens avenues for developing therapeutic strategies aimed at targeting mitochondrial dysfunction, which is increasingly recognized as a hallmark of various pathologies. As the field of mitochondrial research advances, the characterization of COQ4 and its recombinant protein forms will be crucial for uncovering the complexities of CoQ metabolism and its broader implications for health.
