Analytical Data
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Gene name
CSK
- Application
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Alternative Names
CSK；Tyrosine-Protein kinase CSK
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41240
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Expression Region
2-450aa
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AA Sequence
SAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSK (C-terminal Src kinase) is an important regulator of the Src family of tyrosine kinases, which play crucial roles in various cellular processes, including proliferation, differentiation, and survival. The study of CSK has garnered significant interest due to its regulatory functions and potential implications in cancer and other diseases. CSK inhibits Src family kinases by phosphorylating them on a specific tyrosine residue, thus maintaining cellular homeostasis. Dysregulation of this pathway can lead to abnormal cell signaling, contributing to tumorigenesis. Research into the structure and function of CSK, especially in the context of its interactions with other proteins and cellular pathways, can provide insights into its role in health and disease. Moreover, understanding how CSK is regulated offers potential avenues for therapeutic intervention in diseases associated with aberrant Src kinase activity. Given the complexity of cellular signaling networks, studies utilizing recombinant CSK proteins have become essential for elucidating its mechanisms of action, exploring novel inhibitors, and developing strategies to modulate its activity in pathological conditions.
