Cat: PAX2000-11302

Recombinant Human SHQ1 Protein,His

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Analytical Data

  • Gene name

    SHQ1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    SHQ1; Protein SHQ1 homolog

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q6PI26

  • Expression Region

    1-577 aa

  • AA Sequence

    MLTPAFDLSQ DPDFLTIAIR VPYARVSEFD VYFEGSDFKF YAKPYFLRLT LPGRIVENGS EQGSYDADKG IFTIRLPKET PGQHFEGLNM LTALLAPRKS RTAKPLVEEI GASEIPEEVV DDEEFDWEIE QTPCEEVSES ALNPQCHYGF GNLRSGVLQR LQDELSDVID IKDPDFTPAA ERRQKRLAAE LAKFDPDHYL ADFFEDEAIE QILKYNPWWT DKYSKMMAFL EKSQEQENHA TLVSFSEEEK YQLRKFVNKS YLLDKRACRQ VCYSLIDILL AYCYETRVTE GEKNVESAWN IRKLSPTLCW FETWTNVHDI MVSFGRRVLC YPLYRHFKLV MKAYRDTIKI LQLGKSAVLK CLLDIHKIFQ ENDPAYILND LYISDYCVWI QKVKSKKLAA LAEALKEVSL TKAQLGLELE ELEAAALLVQ EEETALKAAH SVSGQQTLCS SSEASDSEDS DSSVSSGNED SGSDSEQDEL KDSPSETVSS LQGPFLEESS AFLIVDGGVR RNTAIQESDA SQGKPLASSW PLGVSGPLIE ELGEQLKTTV QVSEPKGTTA VNRSNIQERD GCQTPNN

  • Molecular Weight

    65.1 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

SHQ1, a crucial co-factor in the assembly of the telomerase complex, has gained attention in recent years due to its role in maintaining telomere integrity and regulating cellular aging and proliferation. Research indicates that SHQ1 facilitates the proper folding and stabilization of the telomerase RNA component (TERC), which is essential for the enzymatic activity of telomerase. Dysfunctional telomerase activity is linked to various diseases, including cancer and degenerative disorders, making SHQ1 a significant target for therapeutic interventions. Furthermore, studies have shown that SHQ1 interacts with multiple proteins involved in telomere maintenance and DNA damage response pathways, highlighting its multifaceted role in cellular homeostasis. Understanding the structural and functional properties of SHQ1 through recombinant protein studies can provide insights into its mechanism of action and potential implications in disease modeling and drug development. As a result, the recombinant expression of SHQ1 is of high importance for elucidating its biological functions and exploring its potential as a biomarker or therapeutic target in the context of telomere-related diseases.

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