Analytical Data
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基因名
COMMD3
- Application
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别名
COMMD3; BUP; C10orf8COMM domain-containing protein 3; Protein Bup; Protein PIL
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBI1
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表达区间
1-195aa
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氨基酸序列
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVGKLKDASKSLERATQS
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分子量
46.97 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COMMD3 (COMM domain-containing protein 3) is a member of the COMMD protein family, which plays a crucial role in various cellular processes, including cellular signaling, copper transport, and protein stability. Its involvement in the regulation of NF-κB signaling, a key pathway associated with inflammatory responses and cell survival, has garnered attention in the context of disease mechanisms. Recent studies have suggested that COMMD3 may act as a modulator of protein interactions, influencing the degradation pathways of specific targets. Additionally, COMMD3 has been implicated in the dynamics of intracellular copper, linking it to metabolic disorders and certain cancers where copper homeostasis is disrupted. Given these multifaceted roles, the recombinant expression of COMMD3 protein is essential for elucidating its biological functions, exploring its potential as a therapeutic target, and understanding its interactions at the molecular level. Investigating COMMD3 through recombinant techniques allows researchers to produce the protein in controlled environments, facilitating biophysical and biochemical analyses. Thus, the study of COMMD3 recombinant protein not only contributes to our understanding of its physiological roles but also holds promise for advancing therapeutic strategies against diseases where COMMD3 is implicated.
