Analytical Data
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基因名
COMMD8
- Application
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别名
COMMD8; MDS022; COMM domain-containing protein 8
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NX08
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表达区间
1-183aa
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氨基酸序列
MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK
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分子量
47.5 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COMMD8, a member of the COMMD (COMM domain-containing) protein family, has garnered interest in recent years due to its potential roles in cellular processes such as protein trafficking, transcriptional regulation, and maintaining cellular homeostasis. The COMMD family is characterized by the presence of a COMM domain, which facilitates interactions with a variety of proteins, suggesting a diverse range of biological functions. Initial studies have indicated that COMMD8 may be involved in the regulation of copper metabolism and the modulation of NF-κB signaling pathways, both of which are critical in the context of various diseases, including cancer and inflammatory disorders. Furthermore, COMMD8 has been linked to the cellular response to oxidative stress, making it a significant player in the study of cellular survival and apoptosis. Exploring the recombinant protein of COMMD8 can provide insights into its structural and functional properties, allowing for a deeper understanding of its mechanisms of action. This research could potentially lead to novel therapeutic strategies targeting diseases associated with dysregulated COMMD8 activity, highlighting its importance as a biomarker or therapeutic target in conditions such as neurodegenerative diseases and cancer. Overall, the study of COMMD8 recombinant protein is crucial for unraveling its biological significance and therapeutic potential in disease contexts.
