Analytical Data
-
Gene name
SH2D4A
- Application
-
Alternative Names
FLJ20967; PPP1R38; Protein phosphatase 1 regulatory subunit 38; Protein SH; Protein SH(2)A; Protein SH2A ; SH2 domain containing 4A; SH2 domain containing protein 4A; SH2 domain-containing protein 4A; SH24A_HUMAN; SH2A ; Sh2d4a
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9H788
-
Expression Region
1-454 aa
-
AA Sequence
MLKQILSEMY IDPDLLAELS EEQKQILFFK MREEQIRRWK EREAAMERKE SLPVKPRPKK ENGKSVHWKL GADKEVWVWV MGEHHLDKPY DVLCNEIIAE RARLKAEQEA EEPRKTHSEE FTNSLKTKSQ YHDLQAPDNQ QTKDIWKKVA EKEELEQGSR PAPTLEEEKI RSLSSSSRNI QQMLADSINR MKAYAFHQKK ESMKKKQDEE INQIEEERTK QICKSWKEDS EWQASLRKSK AADEKRRSLA KQAREDYKRL SLGAQKGRGG ERLQSPLRVP QKPERPPLPP KPQFLNSGAY PQKPLRNQGV VRTLSSSAQE DIIRWFKEEQ LPLRAGYQKT SDTIAPWFHG ILTLKKANEL LLSTGMPGSF LIRVSERIKG YALSYLSEDG CKHFLIDASA DAYSFLGVDQ LQHATLADLV EYHKEEPITS LGKELLLYPC GQQDQLPDYL ELFE
-
Molecular Weight
52.7 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SH2D4A, also known as Src Homology 2 Domain-containing protein 4A, is a member of the SH2D family, which is involved in various cellular processes, including signal transduction and immune response regulation. It plays a pivotal role in modulating T-cell activation and has been linked to immune-related disorders. Research has suggested that SH2D4A interacts with critical signaling pathways, thereby influencing cellular signaling dynamics and gene expression. Given its involvement in immune cell function, studying SH2D4A can provide insights into the molecular mechanisms underlying autoimmune diseases, chronic inflammatory conditions, and potentially cancer. The recombinant protein expression of SH2D4A allows for detailed biophysical and biochemical characterization, facilitating the exploration of its functional roles. Investigating the structure and function of SH2D4A through recombinant technology can elucidate its interactions with other signaling molecules and its impact on immune system regulation. This research not only contributes to the understanding of immune mechanisms but also holds therapeutic potential for targeting SH2D4A in related pathologies, making it a significant focus in contemporary biomedical research.
