Analytical Data
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Gene name
INSR
- Application
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Alternative Names
INSR；Insulin receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P06213
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Expression Region
1011-1382aa
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AA Sequence
YVPDEWEVSR EKITLLRELG QGSFGMVYEG NARDIIKGEA ETRVAVKTVN ESASLRERIE FLNEASVMKG FTCHHVVRLL GVVSKGQPTL VVMELMAHGD LKSYLRSLRP EAENNPGRPP PTLQEMIQMA AEIADGMAYL NAKKFVHRDL AARNCMVAHD FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMAPESLKD GVFTTSSDMW SFGVVLWEIT SLAEQPYQGL SNEQVLKFVM DGGYLDQPDN CPERVTDLMR MCWQFNPKMR PTFLEIVNLL KDDLHPSFPE VSFFHSEENK APESEELEME FEDMENVPLD RSSHCQREEA GGRDGGSSLG FKRSYEEHIP YTHMNGGKKN GRILTLPRSN PS
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The insulin receptor (INSR) is a critical protein involved in glucose metabolism, cellular growth, and differentiation, making it a key player in the regulation of energy homeostasis and metabolic disorders such as type 2 diabetes and obesity. The INSR is a transmembrane receptor that initiates signaling cascades in response to insulin binding, resulting in various physiological effects, including enhanced glucose uptake and lipid metabolism. Due to its significant role in metabolic diseases, understanding the structure and function of INSR has become a priority in biomedical research. Recombinant protein technology has emerged as a powerful tool for studying INSR, allowing researchers to produce large quantities of this protein for biochemical assays, structural analyses, and therapeutic applications. By generating recombinant INSR, scientists can investigate its domain structure, ligand interactions, and signaling mechanisms, which are essential for deciphering how insulin resistance develops at the molecular level. Additionally, recombinant INSR can be used to screen potential drug candidates aimed at improving insulin sensitivity, providing insights that could lead to novel treatments for metabolic diseases. Overall, research on recombinant INSR not only furthers our understanding of insulin signaling but also holds promise for developing strategies to combat insulin resistance and related disorders.
