Analytical Data
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基因名
SH2D3A
- Application
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别名
Novel SH2 containing protein 1 ; Novel SH2-containing protein 1; NSP1; SH2 domain containing 3A; SH2 domain containing protein 3A; SH2 domain-containing protein 3A; SH23A_HUMAN; SH2D3A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BRG2
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表达区间
1-576 aa
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氨基酸序列
MQVPQDGEDL AGQPWYHGLL SRQKAEALLQ QNGDFLVRAS GSRGGNPVIS CRWRGSALHF EVFRVALRPR PGRPTALFQL EDEQFPSIPA LVHSYMTGRR PLSQATGAVV SRPVTWQGPL RRSFSEDTLM DGPARIEPLR ARKWSNSQPA DLAHMGRSRE DPAGMEASTM PISALPRTSS DPVLLKAPAP LGTVADSLRA SDGQLQAKAP TKPPRTPSFE LPDASERPPT YCELVPRVPS VQGTSPSQSC PEPEAPWWEA EEDEEEENRC FTRPQAEISF CPHDAPSCLL GPQNRPLEPQ VLHTLRGLFL EHHPGSTALH LLLVDCQATG LLGVTRDQRG NMGVSSGLEL LTLPHGHHLR LELLERHQTL ALAGALAVLG CSGPLEERAA ALRGLVELAL ALRPGAAGDL PGLAAVMGAL LMPQVSRLEH TWRQLRRSHT EAALAFEQEL KPLMRALDEG AGPCDPGEVA LPHVAPMVRL LEGEEVAGPL DESCERLLRT LHGARHMVRD APKFRKVAAQ RLRGFRPNPE LREALTTGFV RRLLWGSRGA GAPRAERFEK FQRVLGVLSQ RLEPDR
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分子量
63.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SH2D3A (SH2 Domain Containing 3A) is a protein that plays a significant role in intracellular signaling pathways, particularly in immune response and cell communication. Research into SH2D3A has gained momentum due to its involvement in various cellular processes, including T-cell activation and differentiation. This protein contains an SH2 domain, which is crucial for binding to phosphorylated tyrosine residues on target proteins, facilitating signal transduction. Studies have indicated that SH2D3A may also interact with other signaling molecules, influencing pathways associated with cell survival and proliferation. Given its potential roles in oncogenesis and immune disorders, understanding the structure, function, and regulatory mechanisms of SH2D3A is imperative. Recent advances in recombinant protein technology have enabled the production of SH2D3A in laboratory settings, allowing for detailed biochemical and biophysical analyses. This research is vital for elucidating the precise mechanisms through which SH2D3A contributes to cellular signaling and its implications in health and disease. By investigating its functional properties and interactions, scientists hope to identify SH2D3A as a potential therapeutic target for immune-related diseases and cancers, paving the way for innovative treatment strategies.
