Analytical Data
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基因名
COG8
- Application
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别名
COG8; Conserved oligomeric Golgi complex subunit 8; COG complex subunit 8; Component of oligomeric Golgi complex 8
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96MW5
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表达区间
1-219aa
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氨基酸序列
MNSYMLISAPAILGTSNMPAAVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGALEDALAKVTKIILAFHRAEEAAFSSGEQELFVQFCTVFLEDLVPYLNRCLQVLFPPAQIAQTLGIPPTQLSKYGNLGHVNIGAIQEPLAFILPKRETLFTLDDQALGPELTAPAPEPPAEEPRLEPAGPACPEGGRAETQAEPPSVGP
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分子量
49.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COG8, a member of the Conserved Oligomeric Golgi (COG) complex, plays a critical role in maintaining Golgi apparatus integrity and function, which is essential for intracellular transport and glycoprotein processing. Research on COG8 has gained traction due to its involvement in several cellular processes, particularly those related to membrane trafficking and protein glycosylation. Mutations in the COG complex, including COG8, have been linked to congenital disorders, such as COG8 deficiency, resulting in cognitive impairments, developmental delays, and immunological issues, underlining its importance in human health. Understanding COG8's structure and function is crucial for revealing the mechanisms underlying these diseases and may open avenues for targeted therapeutic strategies. Recent advances in protein engineering and cryo-electron microscopy have provided insights into the oligomeric structure and interactions of COG8 within the COG complex, spurring interest in its potential as a biomarker for disease diagnosis and progression. Overall, the study of COG8 not only enhances our understanding of Golgi function but also holds promise for improving clinical outcomes in patients with COG-related disorders.
