Analytical Data
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Gene name
TLK2
- Application
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Alternative Names
TLK2；Serine/threonine-Protein kinase tousled-like 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86UE8
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Expression Region
1-772aa
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AA Sequence
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
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Molecular Weight
87kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TLK2 (Tousled-like kinase 2) is a serine/threonine kinase that plays a crucial role in DNA damage response and cell proliferation. Its expression is associated with several cellular processes, including chromatin remodeling, repair of DNA double-strand breaks, and regulation of the cell cycle. Dysregulation of TLK2 has been linked to various cancers, underscoring its potential as a biomarker for tumor diagnosis and a therapeutic target. Recent studies have focused on the recombinant expression of TLK2 to elucidate its functional mechanisms and interactions within cellular pathways. Recombinant TLK2 protein provides a valuable tool for understanding its enzymatic activity, substrate specificity, and role in oncogenic signaling. By investigating the interactions of TLK2 with other proteins involved in the DNA damage response, researchers aim to develop novel therapeutic strategies that can enhance DNA repair mechanisms in cancer cells or inhibit TLK2 activity in oncogenic contexts. These studies not only aim to characterize TLK2’s role in cell biology but also provide insights into its potential implications in cancer treatment, making it a focal point for ongoing cancer research and drug development initiatives. The production of recombinant TLK2 in various expression systems enables high-throughput screening and functional assays, which are essential for advancing our understanding of its biological significance and therapeutic potential.
