Analytical Data
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基因名
COG6
- Application
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别名
Conserved oligomeric Golgi complex subunit 6. COG complex subunit 6. Component of oligomeric Golgi complex 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2V7
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表达区间
1-657aa
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氨基酸序列
MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQAAKEQTQDLIVKTTKLQSESQKLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYRWAQSECRTLTQESCDVSPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTTQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIVGNSATALLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLMLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTVQQHKPEQGSLANMPNLDSVTLKAAMVQFDRYLSAPDNLLIPQLNFLLSATVKEQIVKQSTELVCRAYGEVYAAVMNPINEYKDPENILHRSPQQVQTLLS
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分子量
73.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COG6, part of the conserved oligomeric Golgi (COG) complex, plays a crucial role in the maintenance of Golgi apparatus structure and function. The COG complex is vital for the retrograde transport of proteins from the Golgi back to the endoplasmic reticulum, influencing various cellular processes, including glycosylation and protein sorting. Mutations or disruptions in COG6 have been linked to congenital disorders of glycosylation (CDG), which are characterized by a wide range of developmental and neurological impairments. Research into COG6 recombinant proteins aims to elucidate the molecular mechanisms underlying these processes and to explore potential therapeutic avenues for conditions related to COG dysfunction. Given its central role in cellular trafficking and protein processing, COG6 is a promising target for research focused on glycoprotein maturation and disease pathology. Understanding the structure and function of COG6 at a molecular level could provide insights into the broader implications of Golgi apparatus regulation and its impact on cellular health and development. Furthermore, the production of recombinant COG6 can facilitate the development of assays for drug screening and the identification of potential small-molecule inhibitors that might help in correcting the malfunction caused by its deficiency, thus offering hope for therapeutic interventions in related diseases.
