Analytical Data
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基因名
SGSM3
- Application
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别名
Bdif 1; Cip85; Cx43 interacting protein of 85 kDa; MAP; Merlin associated protein; merlin binding protein; Merlin-associated protein; R75178; rab GTPase activating protein like protein; Rab-GTPase-activating protein-like protein; RABGAP5; rabGAPLP; RUN and SH3 containing 3; RUN and TBC1 domain containing 3; RUN and TBC1 domain containing protein 3; RUN and TBC1 domain-containing protein 3; RUN and TBC1 domains-containing protein 3; RUSC3; RUTBC3; SGSM3; SGSM3_HUMAN; Small G protein signaling modulator 3; Small G protein signaling modulator 3 protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96HU1
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表达区间
1-749 aa
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氨基酸序列
MSGSHTPACG PFSALTPSIW PQEILAKYTQ KEESAEQPEF YYDEFGFRVY KEEGDEPGSS LLANSPLMED APQRLRWQAH LEFTHNHDVG DLTWDKIAVS LPRSEKLRSL VLAGIPHGMR PQLWMRLSGA LQKKRNSELS YREIVKNSSN DETIAAKQIE KDLLRTMPSN ACFASMGSIG VPRLRRVLRA LAWLYPEIGY CQGTGMVAAC LLLFLEEEDA FWMMSAIIED LLPASYFSTT LLGVQTDQRV LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVD IKLLLRIWDL FFYEGSRVLF QLTLGMLHLK EEELIQSENS ASIFNTLSDI PSQMEDAELL LGVAMRLAGS LTDVAVETQR RKHLAYLIAD QGQLLGAGTL TNLSQVVRRR TQRRKSTITA LLFGEDDLEA LKAKNIKQTE LVADLREAIL RVARHFQCTD PKNCSVELTP DYSMESHQRD HENYVACSRS HRRRAKALLD FERHDDDELG FRKNDIITIV SQKDEHCWVG ELNGLRGWFP AKFVEVLDER SKEYSIAGDD SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV ERDFASVYSR LVLCKTFRLD EDGKVLTPEE LLYRAVQSVN VTHDAVHAQM DVKLRSLICV GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK CELRVLCCFA FSLSQDWELP AKREAQQPLK EGVRDMLVKH HLFSWDVDG
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分子量
85.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SGSM3, or Src homology 3 (SH3) domain and multiple ankyrin repeat domains 3, is a member of the SGSM family of proteins that play critical roles in cellular signaling and cytoskeletal dynamics. Research on SGSM3 has gained momentum due to its involvement in various physiological processes and its potential implications in pathological conditions such as cancer and neurodegenerative diseases. SGSM3 is known to function as a scaffolding protein, facilitating the assembly of signal transduction complexes and regulating the activity of various kinases and phosphatases. This protein is also implicated in endocytic processes and cell adhesion, influencing cellular interaction with the extracellular matrix. Understanding the molecular mechanisms by which SGSM3 contributes to these processes is essential for elucidating its role in health and disease. Given its central role in signaling pathways, SGSM3 has emerged as a target for therapeutic intervention, with research aimed at developing specific inhibitors or modulators that could provide new avenues for treatment in diseases where SGSM3 is dysregulated. Furthermore, exploring the structural characteristics of SGSM3 may reveal insights into its interaction with other proteins and its functional diversity, underscoring the importance of studying this protein in a broader biological context. Overall, the investigation of SGSM3 represents a promising area of study with significant implications for both basic biology and clinical applications.
