Analytical Data
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基因名
SGOL1
- Application
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别名
hSgo 1; hSgo1; NY BR 85; Serologically defined breast cancer antigen NY BR 85 ; Serologically defined breast cancer antigen NY-BR-85; SGO 1; SGO; SGO L1; SGO1; SGOL 1; SGOL1; SGOL1_HUMAN; Shugoshin 1AB protein; Shugoshin 1CD protein; Shugoshin 1EFprotein; Shugoshin 1GH protein; Shugoshin 1KL protein; Shugoshin like 1 (S. pombe); Shugoshin like 1; Shugoshin-like 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5FBB7
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表达区间
1-561 aa
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氨基酸序列
MAKERCLKKS FQDSLEDIKK RMKEKRNKNL AEIGKRRSFI AAPCQIITNT STLLKNYQDN NKMLVLALEN EKSKVKEAQD IILQLRKECY YLTCQLYALK GKLTSQQTVE PAQNQEICSS GMDPNSDDSS RNLFVKDLPQ IPLEETELPG QGESFQIEDQ IPTIPQDTLG VDFDSGEAKS TDNVLPRTVS VRSSLKKHCN SICQFDSLDD FETSHLAGKS FEFERVGFLD PLVNMHIPEN VQHNACQWSK DQVNLSPKLI QPGTFTKTKE DILESKSEQT KSKQRDTQER KREEKRKANR RKSKRMSKYK ENKSENKKTV PQKKMHKSVS SNDAYNFNLE EGVHLTPFRQ KVSNDSNREE NNESEVSLCE SSGSGDDSDD LYLPTCKYIQ NPTSNSDRPV TRPLAKRALK YTDEKETEGS KPTKTPTTTP PETQQSPHLS LKDITNVSLY PVVKIRRLSL SPKKNKASPA VALPKRRCTA SVNYKEPTLA SKLRRGDPFT DLCFLNSPIF KQKKDLRRSK KRALEVSPAK EAIFILYYVR EFVSRFPDCR KCKLETHICL R
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分子量
64.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SGOL1 (Sgo1) is a crucial protein involved in the regulation of chromosome segregation during cell division. It plays a significant role in ensuring the accurate distribution of chromosomes to daughter cells, thus maintaining genomic stability. Aberrations in chromosome segregation can lead to aneuploidy and contribute to various diseases, including cancer. The importance of SGOL1 is underscored by its function in the spindle assembly checkpoint, where it helps to prevent anaphase onset until all chromosomes are properly attached to the mitotic spindle. This checkpoint is vital for cellular integrity and the prevention of tumorigenesis.
Research into SGOL1, particularly through the development of recombinant proteins, is essential for elucidating its mechanisms of action and interactions with other cell cycle regulators. By studying the recombinant SGOL1 protein, researchers can explore its structural features, binding partners, and functional domains, which could pave the way for novel therapeutic strategies targeting dysregulated cell division. Furthermore, understanding the role of SGOL1 in various cellular contexts enhances our knowledge of its potential as a biomarker for certain cancers and as a target in cancer therapy. Thus, the investigation of SGOL1 recombinant protein not only contributes to fundamental cell biology but also holds promise for advancing cancer treatment and improving outcomes for patients with chromosomal instability.
