Analytical Data
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基因名
COG2
- Application
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别名
Brefeldin A sensitive peripheral Golgi protein; CDG2Q; COG 2; COG complex subunit 2; COG2; COG2_HUMAN; Component of oligomeric Golgi complex 2; Conserved oligomeric Golgi complex component 2; Conserved oligomeric Golgi complex subunit 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14746
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表达区间
1-738aa
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氨基酸序列
MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP
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分子量
107.58 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COG2, a member of the conserved oligomeric Golgi (COG) complex, plays a critical role in intracellular membrane trafficking and maintaining Golgi structure and function. The COG complex is essential for proper glycosylation of proteins and lipids, influencing various cellular processes, including secretion, signal transduction, and cell adhesion. Mutations or dysfunctions in COG2 have been linked to several human diseases, particularly congenital disorders related to glycosylation, which can lead to severe developmental and functional abnormalities. Researchers are increasingly focused on the study of COG2 recombinant protein to understand its precise molecular mechanisms and interactions within the COG complex. By producing COG2 as a recombinant protein, scientists aim to elucidate its role in Golgi dynamics, identify binding partners, and develop therapeutic strategies to address COG-related disorders. The ability to generate high-purity recombinant COG2 facilitates in vitro studies that may reveal the structural and functional properties of this protein, further shedding light on its contribution to cellular homeostasis and the pathogenesis of associated diseases. Therefore, research on COG2 not only enhances our understanding of fundamental cellular processes but also holds potential for informing the development of innovative treatments for glycosylation disorders.
